AMG 511 ( AMG-511;AMG511 )

Catalog No. M13756 CAS No. 253573-53-3

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity

Group Booking Get Quotation Bulk Inquiry Add to Cart

Product Name

AMG 511
Note

Research use only, not for human use.
Brief Description

A potent, efficacious, and orally available pan class I PI3K inhibitor.
Description

A potent, efficacious, and orally available pan class I PI3K inhibitor with Ki of 4/6/2/1 nM for PI3Kα/β/δ/γ, respectively; displays high selectivity over other members of the closely related PIKK family of kinases, including mTOR, hVPS34 and PI4Ks, as well as a panel of 370 protein kinases (IC50>1 uM); inhibits AKT (Ser473) phosphorylation in U87 MG glioblastoma cells with IC50 of 4 nM; potently blocks the targeted PI3K pathway in mouse liver pharmacodynamic model and inhibits tumor growth in U87 malignant glioma glioblastoma xenograft model.
Synonyms

AMG-511;AMG511
Pathway

PI3K/Akt/mTOR signaling
Target

PI3K
Recptor

PI3K
Research Area

——
Indication

——

CAS Number

253573-53-3
Formula Weight

517.58
Molecular Formula

C22H28FN9O3S
Purity

>98% (HPLC)
Solubility

——
SMILES

——
Chemical Name

(R)-4-(2-((5-Fluoro-6-methoxypyridin-3-yl)amino)-5-(1-(4- (methylsulfonyl)piperazin-1-yl)ethyl)pyridin-3-yl)-6-methyl-1,3,5-triazin-2-amine

1. Norman MH, et al. J Med Chem. 2012 Sep 13;55(17):7796-816.

Calculator

molnova catalog